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Use of melatonin in the complex treatment of psoriasis, À. Lopandina
SE «Institute of Dermatology and Venereology of NAMS of Ukraine»
Abstract
Objective. Presents the results of study the dynamics of melatonin levels, proinflammatory cytokines and vascular endothelial growth
factor in patients with psoriasis before and after traditional and complex treatment.
Materials and methods. The results of the study of severity, sleep disturbance, also melatonin, tumor necrosis factor-α, interleukin
8 and vascular endothelial growth factor levels in 56 patients with psoriasis aged 18–65 years are presented.
The results. Improvement of clinical and laboratory parameters in patients with psoriasis after treatment was observed. Comparative
evaluation of the results of treatment of patients with psoriasis who received traditional treatment and treatment, including the melatonin,
showed the advantage of the developed method.
Conclusions. Complex treatment with the use of melatonin increases the efficacy of therapy, contributes to a more rapid regression
of the clinical manifestations of psoriasis.
Key words: psoriasis, pathogenesis, melatonin, immunity, angiogenesis, treatment, efficacy.